Non-Coding
RNA-Mediated
Regulatory Networks
Non-Coding
RNA-Mediated
Regulatory Networks
At ncRNA-lab we are interested in deciphering the regulatory pathways mediated by non coding RNAs (mainly small ncRNAs) for a better understanding of the molecular mechanisms that allow crops to respond and eventually adapt to biotic and abiotic stress conditions.
Research lines
Regulatory networks of response to stress mediated by miRNAs
In general, plants respond to changes in environmental conditions through a complex transcriptional reprogramming…
miRNAs are fundamental endogenous regulators of gene expression in higher organisms. miRNAs modulate multiple biological processes…
Viroids-host interactions
Viroids are a class of sub-viral plant-pathogenic long noncoding RNAs (240-400 nt) composed of a circular single-stranded molecule. Viroid infection comprises a series of coordinated steps involving…
Eukaryotic organisms exposed to adverse conditions are required to show a certain degree of transcriptional plasticity in order…
Members
Faculty
Gustavo Germán Gómez
CSIC Scientific Researcher
gustavo.gomez@csic.es
Tel: (+34) 963544777
+ info
Gustavo Germán Gómez
CSIC Scientific Researcher
(+34) 963544777
gustavo.gomez@csic.es
+ info
Postdoctoral Researchers
María Carmen Herranz Gordo
BotVid-SENSOR Project
mc.herranz@csic.es
Tel: (+34) 963543996
+ info
María Carmen Marqués Romero
PreDeSTom Project
mc.marques@csic.es
Tel: (+34) 963543996
+ info
PhD Students
Julia Corell Sierra
Predoctoral contract, GVA (ACIF)
julia.corell@csic.es
Tel: (+34) 963544783
+ info
Predoctoral contract, GVA (ACIF)
gabriela.hernandez@csic.es
Tel: (+34) 963544783
+ info
Pascual Villalba Bermell
Predoctoral contract, AEI
pascual.villalba@csic.es
Tel: (+34) 963544783
+ info
Antonio González Sánchez
Predoctoral contract
antonio.gonzalez.sanchez@csic.es
Tel: (+34) 963544783
+ info
Samanta Gissela Silva Valencia
Predoctoral contract, GVA (GRISOLÍA)
samanta.silva@csic.es
Tel: (+34) 963544783
+ info
Miguel Ruiz Ibáñez
Predoctoral contract
m.ruiz.ibanez@csic.es
Tel: (+34) 963544783
+ info
Marta Núñez Salvador
Predoctoral contract
marta.nunez.salvador@csic.es
Tel: (+34) 963544783
+ info
Technical assistant
Vega Tirado Guardia
Lab technician
vega.tirado@csic.es
Tel: (+34) 963543996
+ info
Students
Javier Lozano
TFM IBMCG UV
Tel: 34 963543996
Elisa Soriano
TFG Biotechnology UCV
Tel: 34 963543996
Projects
Current projects
Global-REPaIr
The objective of this project is to understand the molecular basis of the plant-environment interactions at global scale in economically important crops.
PreDeSTom
The objective of this Project is the “Development of a dual strategy for the mitigation of the damage associated to stress, in tomato…
BotVidSENSOR
The objective of the project BotVidSENSOR, is the development of a tool for the diagnosis of the «grey rot» disease, caused by B. cinerea, which allow the EARLY monitoring…
Plant Predictor
Stress-induced changes in plants (including those produced by pests or pathogens) are usually detected by the appearance of visual symptoms, usually once the adverse effects on crop…
EGReNMel
Environmental stresses (largely facilitated by climate change) limit the productive potential of many agricultural species. Faced with adverse environmental…
Global-REPaIr
The objective of this project is to understand the molecular basis of the plant-environment interactions at global scale in economically important crops.
PreDeSTom
The objective of this Project is the “Development of a dual strategy for the mitigation of the damage associated to stress, in tomato…
BotVidSENSOR
The objective of the project BotVidSENSOR, is the development of a tool for the diagnosis of the «grey rot» disease, caused by B. cinerea, which allow the EARLY monitoring…
Plant Predictor
Stress-induced changes in plants (including those produced by pests or pathogens) are usually detected by the appearance of visual symptoms, usually once the adverse effects on crop…
EGReNMel
Environmental stresses (largely facilitated by climate change) limit the productive potential of many agricultural species. Faced with adverse environmental…
Past projects
COV-CRISPIS
Traditional viral infection diagnostic techniques in the clinic are based on (RT-)PCR procedures, which are time consuming and require precise equipment…
Funct. Validation of sncRNA
As consequence of the exposition to stress-inductors plants trigger a complex regulatory response that results in adaptation to adverse conditions. In general…
COV-CRISPIS
Traditional viral infection diagnostic techniques in the clinic are based on (RT-)PCR procedures, which are time consuming and require precise equipment…
Funct. Validation of sncRNA
As consequence of the exposition to stress-inductors plants trigger a complex regulatory response that results in adaptation to adverse conditions. In general…
Projects
Current projects
Past projects
Publications
Relevant Publications
(last ten years)
-
2026
- Artículo de revista Synergistic regulation of abiotic stress adaptation by copper miRNAs miR398 and miR408 in melon The Plant Journal DOI: 10.1111/tpj.71061
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2025
- Preprint Coordinated overexpression of miR398 and miR408 confers broad-spectrum abiotic stress tolerance in melon. DOI: 10.22541/au.176707113.34642115/v1
- Preprint Coordinated overexpression of miR398 and miR408 confers broad-spectrum abiotic stress tolerance in melon DOI: 10.64898/2025.12.11.693700
- Artículo de revista Overexpression of the Receptor‐Like Kinase BIR1 Causes SOBIR1‐ and EDS1‐Dependent Cell Death Phenotypes in Arabidopsis Plant, Cell & Environment DOI: 10.1111/pce.70036
- Artículo de revista Latent infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and cross-protection Nature Communications DOI: 10.1038/s41467-025-62522-2
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2024
- Preprint Exploring the miRNA-mediated response to combined stress conditions in melon plants. DOI: 10.22541/au.170667009.93639773/v1
- Preprint Chronic infection ofCaenorhabditis elegansby Orsay virus induces age-dependent immunity and superinfection exclusion DOI: 10.1101/2024.12.26.630373
- Artículo de revista A multispecies study reveals the diversity and potential regulatory role of long noncoding RNAs in cucurbits The Plant Journal DOI: 10.1111/tpj.17013
- Artículo de revista Hop stunt viroid infection induces heterochromatin reorganization New Phytologist DOI: 10.1111/nph.19986
- Preprint Identification, characterization and transcriptional analysis of the long non-coding RNA landscape in the familyCucurbitaceae DOI: 10.1101/2024.01.12.575433
- Artículo de revista Almond Grafting for Plum Pox Virus Resistance Triggers Significant Transcriptomic and Epigenetic Shifts in Peaches International Journal of Molecular Sciences DOI: 10.3390/ijms26010248
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2023
- Preprint Hop stunt viroid infection alters host heterochromatin DOI: 10.1101/2023.12.12.571286
- Preprint SARS-CoV-2 remodels the landscape of small non-coding RNAs with infection time and symptom severity DOI: 10.21203/rs.3.rs-3375685/v1
- Artículo de revista Integrative time‐scale and multi‐omics analysis of host responses to viroid infection Plant, Cell & Environment DOI: 10.1111/pce.14647
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2022
- Artículo de revista Occurrence of RNA post-transcriptional modifications in plant viruses and viroids and their correlation with structural and functional features. Virus research DOI: 10.1016/j.virusres.2022.198958
- Artículo de revista Author Correction: Alternative processing of its precursor is related to miR319 decreasing in melon plants exposed to cold Scientific Reports DOI: 10.1038/s41598-022-22793-x
- Artículo de revista A circular RNA vector for targeted plant gene silencing based on an asymptomatic viroid The Plant Journal DOI: 10.1111/tpj.15929
- Artículo de revista Diagnostics of Infections Produced by the Plant Viruses TMV, TEV, and PVX with CRISPR-Cas12 and CRISPR-Cas13 ACS Synthetic Biology DOI: 10.1021/acssynbio.2c00090
- Artículo de revista Plant epigenome alterations: an emergent player in viroid-host interactions Virus Research DOI: 10.1016/j.virusres.2022.198844
- Preprint Minimal RNA replicons for targeted gene silencing based on an asymptomatic viroid DOI: 10.1101/2022.02.04.479109
- Preprint Multiomic analisys reveals that viroid infection induces a temporal reprograming of plant-defence mechanisms at multiple regulatory levels DOI: 10.1101/2022.01.06.475203
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2021
- Artículo de revista Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network Frontiers in Plant Science DOI: 10.3389/fpls.2021.769093
- Artículo de revista Symptom Severity, Infection Progression and Plant Responses in Solanum Plants Caused by Three Pospiviroids Vary with the Inoculation Procedure International Journal of Molecular Sciences DOI: 10.3390/ijms22126189
- Otro Exploring the miRNA-mediated response to combined stresses in melon plants bioRxiv DOI: 10.1101/2021.07.30.454429
- Artículo de revista Might exogenous circular RNAs act as protein-coding transcripts in plants? RNA Biology DOI: 10.1080/15476286.2021.1962670
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2020
- Artículo de revista Viral Fitness Determines the Magnitude of Transcriptomic and Epigenomic Reprograming of Defense Responses in Plants Molecular Biology and Evolution DOI: 10.1093/molbev/msaa091
- Artículo de revista Hop stunt viroid: A polyphagous pathogenic RNA that has shed light on viroid-host interactions. Molecular plant pathology DOI: 10.1111/mpp.13022
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2019
- Otro Dynamic architecture and regulatory implications of the miRNA network underlying the response to stress in melon DOI: 10.1101/745653
- Artículo de revista Highly efficient construction of infectious viroid-derived clones Plant Methods DOI: 10.1186/s13007-019-0470-4
- Artículo de revista Inferring the regulatory network of the miRNA-mediated response to biotic and abiotic stress in melon BMC Plant Biology DOI: 10.1186/s12870-019-1679-0
- Otro Viral fitness determines the magnitude of transcriptomic and epigenomic reprogramming of defense responses in plants bioRxiv DOI: 10.1101/2019.12.26.888768
- Artículo de revista Identification and characterization of a stress-responsive TAS3-derived tasiRNAs in melon Plant and Cell Physiology DOI: 10.1093/pcp/pcz131
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2018
- Otro Alternative processing of its precursor is related to miR319 decreasing in melon plants exposed to cold OpenAlex DOI: 10.60692/qx6sh-3j447
- Otro Alternative processing of its precursor is related to miR319 decreasing in melon plants exposed to cold OpenAlex DOI: 10.60692/7p1kd-kjz20
- Artículo de revista Alternative processing of its precursor is related to miR319 decreasing in melon plants exposed to cold Scientific Reports DOI: 10.1038/s41598-018-34012-7
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2017
- Otro Changes in the Host Proteome and Transcriptome Induced by Viroid Infection Viroids and Satellites DOI: 10.1016/b978-0-12-801498-1.00010-3
- Otro Viroid Movement Viroids and Satellites DOI: 10.1016/b978-0-12-801498-1.00008-5
- Capítulo de libro Viroid Movement Viroids and Satellites DOI: 10.1016/B978-0-12-801498-1.00008-5
Funding
Current funding
Former funding
Spanish Ministry of Economy (I+D Retos, 2016-2018) – AGL2016-79825-R.
CSIC (Intramural, 2016-2017).
Spanish Ministry of Economy (Explora, 2015-2016).
SENECYT–Ecuador (Program PROMETEO 2013-2015)
Generalitat Valenciana (Grupos emergentes, 2013-2014).